General information Heparins are mucopolysaccharides whose molecules are of varying lengths. Unfractionated heparin contains molecules of average molecular weight of 12 000–15 000 Da. Low molecular weight heparins contain molecules whose average molecular weight is below 5000 Da. Each formulation…
General information A number of compounds that have, or supposedly have, hemostatic activity are reviewed here. Some of them are obsolete and are included largely for historical interest. Others, such as fibrin glue, are still in use. Aminaphtone Experiments in…
See also Perfluorocarbons General information Oxygen carriers can be divided into two classes: hemoglobin-based oxygen carriers, prepared from hemoglobin of human or bovine origin, and synthetic perfluorocarbons (see separate monograph). Hemoglobin-based oxygen carriers are infusible oxygen-carrying fluids prepared from purified…
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General information Halothane is a non-inflammable hydrocarbon that induces anesthesia, with little tendency to excitement. Contrary to earlier assumptions, halothane is metabolized, the consequences of which are discussed below [ , ]. Organs and systems Cardiovascular Halothane, isoflurane, and sevoflurane…
General information Haloperidol is a butyrophenone neuroleptic drug. Its pharmacokinetics have been reviewed, with special emphasis on interactions [ ]. The enzymes involved in its biotransformation include oxidative cytochrome P450 isoenzymes, carbonyl reductase, and uridine diphosphoglucose glucuronosyltransferase. It is mainly…
General information The halogenated quinolines include clioquinol (iodochlorohydroxyquinoline), diiodohydroxyquinoline, broxyquinoline, and chlorquinaldol (all rINNs). Once regarded as a prophylactic and remedy for simple diarrhea, some of them remain in limited use for special purposes, notably for the treatment of amebiasis…
General information Halofantrine is a phenanthrene-methanol derivative of an aminoalcohol, active against multidrug-resistant Plasmodium falciparum malaria. Halofantrine was known during World War II but was little used at that time. It is slowly and incompletely absorbed with peak concentrations 3.5–6…