General information Interleukin-12, an immunomodulatory cytokine, has potential effects in several cancer and infectious diseases. You’re Reading a Preview Become a Clinical Tree membership for Full access and enjoy Unlimited articles Become membership If you are a member. Log in…
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General information Interleukin-10 is a potent anti-inflammatory and immunosuppressive cytokine with beneficial effects expected in a wide range of diseases [ ]. In healthy volunteers, its adverse effect profile mostly consisted of flu-like symptoms at the highest dose [ ].…
General information Interleukin-6 is produced by T cells, monocytes, fibroblasts, endothelial cells, and keratinocytes, and regulates pleiotropic biological functions. Recombinant interleukin-6 has been evaluated for thrombopoietic and antitumor properties [ ]. General adverse effects and adverse reactions During clinical trials,…
General information Interleukin-4 is a pleiotropic cytokine, mostly produced by activated T cells, which acts on the proliferation and differentiation of B and T lymphocytes and enhances the function of natural killer cells, eosinophils, and mast cells [ ]. It…
General information Interleukin-3 is produced by activated T lymphocytes and stimulates the proliferation and differentiation of the granulocyte, macrophage, eosinophil, basophil, erythroid, megakaryocyte, and mast cell lineages [ ]. Drug studies Observational studies Subcutaneous recombinant interleukin-3 has been investigated in…
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General information Interleukin-1-alfa and interleukin-1-beta are produced by two distinct genes with only 25% homology, but they act through the same receptor and share similar in vitro biological properties. Interleukin-1 on its own has modest antitumor activity and limited hemopoietic…
See also Individual agents General information The interferons, first described in 1957, include at least five natural human glycoproteins (alfa, beta, gamma, omega, and tau). Only the first three types are currently used, and they differ both structurally and antigenically.…
See also Interferons . General information Recombinant interferon gamma (interferon gamma-1b) is currently approved only as an adjunct to antibacterial therapy in chronic granulomatous disease [ ], although its immunoregulatory potential has been investigated in other diseases. Clinical experience with…