General information Pemoline has similar pharmacological actions to dexamfetamine and methylphenidate, and was used in the management of hyperactivity disorders in children. However, the evidence linking pemoline to life-threatening liver failure prompted the Food and Drugs Administration to require the…
General information Pemirolast is a mast-cell stabilizer, like cromoglicate, used in eye-drops for the treatment of allergic disorders [ ]. It has also been used to prevent coronary artery restenosis after the insertion of a stent [ ]. Drug studies…
General information Pemetrexed (LY231514, MTA) is an antifolate congener. It is transported into cells by the reduced folate carrier and undergoes intracellular polyglutamylation, resulting in a persistent cytotoxic metabolite, which targeting several enzymes simultaneously, including dihydrofolate reductase, thymidylate synthase, GARFT,…
General information Pegvisomant is a genetically engineered growth hormone analogue that acts as a growth hormone receptor antagonist and is used to treat acromegaly. Drug studies Observational studies In 229 patients with a 9 year history of acromegaly who were…
General information Pegaptanib is a pegylated anti-VEGF aptamer, which is used to treat wet age-related macular degeneration and diabetic macular edema [ ]. Drug studies Observational studies Adverse reactions to intravitreal injection of pegaptanib (0.3, 1, or 3 mg every…
See also Fluoroquinolones General information Pefloxacin is a fluoroquinolone antibiotic that inhibits Plasmodium falciparum in vitro. It is effective against Plasmodium yoelii infections in mice. General adverse effects and adverse reactions The adverse effects of pefloxacin and reactions to it…
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See also Fluoroquinolones General information Pazufloxacin is an injectable quinolone antibiotic with bactericidal effect against cephalosporin-resistant, carbapenem-resistant, and aminoglycoside-resistant strains of bacteria. Organs and systems You’re Reading a Preview Become a Clinical Tree membership for Full access and enjoy Unlimited…
See also Imatinib General information Pazopanib is a potent, selective, broad-spectrum, multi-targeted inhibitor of receptor tyrosine kinases, including VEGFR-1, VEGFR-2, VEGFR-3, PDGFR-α/β, and c-kit. Total disease control in patients with advanced renal cell carcinoma was 82%. The most common adverse…
General information The family of Passifloraceae contains the single genus Passiflora incarnata , which contains over 500 species. You’re Reading a Preview Become a Clinical Tree membership for Full access and enjoy Unlimited articles Become membership If you are a…