Secondary liver disease stemming from vascular pathology related to heart failure, portal vein obstruction, and Budd-Chiari syndrome represents clinically important conditions associated with significant morbidity and impairment of health-related quality of life. The Liver in Heart Failure Heart failure represents…
Systemic Amebiasis may be complicated by the development of an amebic liver abscess ( Fig. 179.1 ). Entamoeba histolytica (also known as E. histolytica ) represents the most common parasite identified in amebic liver abscess and is a commensal organism…
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Hepatocellular carcinoma (HCC) represents one of the most important and life-threatening complications of chronic liver disease. The 5-year survival of patients with HCC remains sobering despite significant advances in the epidemiology, diagnosis, and management of this disease. The epidemiology of…
Wilson disease (WD) is a rare primary copper overload disorder which was first described in 1912 by the neurologist Samuel Kinnier Wilson as “progressive lenticular degeneration” associated with cirrhosis. However, it was not until 1948 that WD was recognized as…
Granulomatous liver diseases are a common finding which may be precipitated by infectious microbes or in response to systemic inflammatory or autoimmune processes. Granulomatous hepatitis may occasionally be idiopathic in origin in context of a fever of unknown origin. Granulomas…
Liver tumors are commonly identified on diagnostic and screening imaging studies of the abdomen and require careful interpretation to distinguish between benign and malignant disease. Although malignant liver tumors such as hepatocellular carcinoma are described elsewhere (see Chapter 177 ),…
Liver disease in pregnancy presents unique challenges to the clinician and requires careful and timely assessment. In addition to unique changes in the clinical course of chronic liver diseases (e.g., hepatitis B) which may occur during the course of pregnancy…
Hereditary hemochromatosis (HH) represents one of several primary iron overload disorders, such as aceruloplasminemia, ahypotransferrinemia, H-ferritin–associated iron overload, and African iron overload syndrome, and should be distinguished from secondary iron overload disorders such as dietary or parenteral iron overload, chronic…
α 1 -Antitrypsin (α 1 -AT) deficiency is a rare inherited liver disorder associated with both chronic liver disease and chronic obstructive pulmonary disease (COPD) with emphysema. It is recognized as the most common genetic liver disease in infants and…