Cardiac Point-of-Care Ultrasound: Background, Instrumentation, and Technique


When a Stat Echo is Not Fast Enough

Developed for military triage, POCUS techniques easily translated to use by trauma surgeons and emergency room physicians, exemplified by the development of the Focused Abdominal Sonography for Trauma (FAST) exam in the early 1990s to diagnose traumatic intraperitoneal bleeding. Point-of-care ultrasound (POCUS) capitalizes on the immediacy and utility of ultrasound at the bedside, especially when initial triage and clinical urgency demand action or when findings are intermittent and fleeting.

The immediate clinical value of limited cardiac ultrasound data obtained from POCUS disrupts the standard conventions of the detailed-oriented philosophy and comprehensive format of standard echocardiography. The advent of portable devices ( Fig. 16.1 ) opened new markets for development in emergency, critical care, internal medicine, and family medicine and has created novel terminology distinct from the practice of echocardiography, using descriptors such as “hand-carried” or “handheld” ultrasound, “quick-look” studies, “focused cardiac ultrasound,” and more recently “point-of-care ultrasound.” No term has yet sufficiently distinguished POCUS practice from that of echocardiography because a “stat echo” also can be performed at the “point of care” using the smaller echocardiographs and recording equivalent data.

Figure 16.1, Point-of-care ultrasound instrumentation and technique, pocket-sized devices. A, Two-dimensional imaging shows midline longitudinal view of a nonpalpable 4.0-cm abdominal aortic aneurysm (Acuson P10, 2- to 4-MHz phased array transducer, Siemens Medical Solutions USA, approved 2007). B, Color Doppler can localize murmurs as specific valvular lesions such as severe mitral regurgitation causing left atrial enlargement (Vscan, 1.7- to 3.8-MHz phased array transducer, GE Healthcare, approved 2009). C, High-frequency probe detects subclinical atherosclerosis as carotid plaque (arrow) (MobiUS SP1, 7.5- to 12-MHz mechanical interchangeable transducer, smartphone connected, Mobisante, approved 2011). D, Spectral pulsed-wave Doppler can assess left ventricular diastolic filling patterns (Sonimage P3, 3- to 5-MHz mechanical interchangeable transducer, Konica Minolta Healthcare Americas, approved 2013). E, Device connectivity to smartphone allows app-based remote imaging guidance (inset) (Lumify,S4-1 MHz phased array transducer, Philips Healthcare, approved 2015). F, Multifrequency imaging probe with connection to smartphone allows cloud-based image texting (inset) (Butterfly iQ, approved 2017).

Pocus: Intents and Purposes

Defining characteristics of current POCUS practice include the imaging of only a few ultrasound findings, performance by the treating physician, and indications to assist in the immediate diagnosis, treatment, triage, or risk stratification of the patient ( Table 16.1 ). With on-the-spot imaging and diagnosis, POCUS will change current standards of imaging and interpretation in ultrasonography. Despite common features in individual specialty use, cardiac POCUS practice is evolving but appears bounded by two distinct imaging philosophies:

  • 1.

    A generalized practice, in which POCUS is used routinely whenever a stethoscope is used in ultrasound-augmented physical examination (UAPE) or,

  • 2.

    A subspecialized practice as a formal limited echocardiogram directed to answer specific clinical questions that may arise after initial clinical evaluation.

Table 16.1
Characteristics of Point-Of-Care Ultrasound Examinations
  • 1.

    Performed by the physician at the bedside during clinical evaluation

  • 2.

    Limited number of findings sought, usually brief (<5 minutes)

  • 3.

    Can encompass more than one organ system

  • 4.

    Has indication and value to immediately affect diagnosis, management, or triage

  • 5.

    Uses small, inexpensive portable devices with limited data entry and measurement packages

  • 6.

    Limited reporting, often semiquantitative

  • 7.

    Often repeated by subsequent physicians and used for monitoring or follow-up

  • 8.

    Often lacks characterization of incidental findings

  • 9.

    Variable imaging and training for each physician

Although real-world POCUS practice often consists of both philosophies to some degree, these two polar boundaries of POCUS have differential impact on medical education, competency requirements, and the approach to medical testing and reimbursement.

POCUS, when practiced to augment the physical examination, is best done by the physician taking care of the patient as a directed search for a simplified ultrasound signs, each a clue to formation of a preliminary diagnosis. The POCUS equivalents of cardiac physical findings improve their detection while allowing the continued use of the same time-honored cardiac physiologic concepts taught in medical school ( Table 16.2 ) . Potential applications are similar to the use of the stethoscope and include initial and frequent reapplications at initial presentation, during subsequent hospital rounds, or in clinic visits. An evidence-based POCUS technique named cardiovascular-limited ultrasound examination (CLUE) has been validated and is a compilation of six easily learned, quick-look ultrasound signs performed within a 2-minute examination ( Fig. 16.2 ). Notably, the CLUE has shown both diagnostic and prognostic value in outpatients and inpatients referred for echocardiography, , as well as in patients admitted by hospitalists. The CLUE represents a proof-of-concept POCUS exam—one that improves traditional bedside physical examination techniques for prognostic findings and has been successfully incorporated into the curriculum of an internal medicine residency program in which residents have proven its effectiveness. Any significant abnormality found on bedside examination—whether by ultrasound or auscultation and palpation—can be documented as a part of the physical examination and is taken into consideration for confirmation by formal echocardiographic study or consultation, time permitting. Because clinically relevant ultrasound techniques can be successfully taught in medical school , or internal medical residency, , ultrasound-augmented physical examination may be a gateway for all physicians to learn POCUS. Ultimately, physicians’ use of UAPE to improve their evaluation and management is an individual assessment of its incremental value in clinical context.

Table 16.2
Physical Exam and Point-Of-Care Ultrasound Findings
From Kimura BJ: Point-of-care cardiac ultrasound techniques in the physical exam: better at the bedside. Heart 103:987–994, 2017.
Entity Physical Finding (SN, SP) POCUS Finding (SN, SP) Notes
LV systolic dysfunction S3 (11%–51%, 85%–98%), (13%, 98%) in ED Subjective estimation of contraction and/or EPSS >1 cm (69%–94%, 88%–94%) US criteria vary between studies; both are easily learned and are reproducible by noncardiologists
Prevalence of physical findings in LVSD is <20%, and even lower in asymptomatic LVSD
Displaced apical impulse (5%–66%, 93%–99%)
15% incidence in symptomatic HFrEF cohort
Elevated LA filling pressures S4 (35%–71%, 50%–70%) LAE (53%–75%, 72%–94%) LAE is prognostic and not found by physical examination
US is learned after brief training
Pulmonary edema or interstitial disease Rales (19%–64%, 82%–94%), (62%, 68%) in ED B lines (85%–98%, 83%–93%) B lines are US artifacts and potentially vary between devices
US is easily learned by novices
Prevalence of 13% in HFrEF cohort
Pleural effusion Dullness to percussion (73%–89%, 81%–91%) Fluid in thorax (64%–90%, 72%–95%) Studies of physical findings used CXR as gold standard, whereas US used CT
Significant increases in SN with US, especially for small effusions
RV enlargement or pulmonary hypertension Sustained left parasternal lift (71%, 80%) RV/LV > 1 (55%, 69%) Nonspecific finding of RVE is seen RVMI, submassive PE, and chronic or pulmonale
Expert US practice needed to use spectral Doppler
Elevated central venous pressures JVP (47%–92%, 93%–96%) (37%, 87%) in ED, 22% incidence in HFrEF cohort IVC plethora (73%, 85%) POCUS advantages in supine ICU patients
POCUS data include nonexperts
JVP by US correlates with physical estimates but underestimates catheter-confirmed pressure
Valve regurgitation Murmur for mild or worse: MR (56%–75%, 89%–93%) or AI (54%–87%, 75%–98%) Color Doppler (82%, 93%) for mild severity Color Doppler jet area limitations apply
Expert practice likely necessary to quantify severity
Severe AS Late-peaking murmur (83%–90%, 72%–88%) Restricted cusp mobility (85%, 89%) Expert auscultation coupled with POCUS may be the best screening method
AI, Aortic insufficiency; CXR, chest radiography; AS, aortic stenosis; ED, emergency department; EPSS, E-point septal separation: HFrEF, heart failure with reduced ejection fraction; ICU, intensive care unit; IVC, inferior vena cava; JVP, jugular venous pulsations; LA, left atrium; LAE, left atrial enlargement; LV, left ventricle; LVSD, left ventricular systolic dysfunction; MR, mitral regurgitation; PE, pulmonary embolism; POCUS, point-of-care ultrasound; RV, right ventricular; RVE, right ventricular enlargement; RVMI, right ventricular myocardial infarction; SN, sensitivity; SP, specificity; US, ultrasound.

Figure 16.2, Cardiovascular-limited ultrasound examination (CLUE) protocol, hand position, and normal versus abnormal findings. The six CLUE signs and seven hand positions are probe sited shown with resultant views, when the sign is absent (normal) or present (abnormal) . Longitudinal images are oriented with cranial to the right. IVC, Inferior vena cava; LAE, left atrial enlargement; RVE, right ventricular enlargement.

POCUS, when practiced as a form of limited echocardiography, can be differentiated from UAPE in an expert consensus document of the American Society of Echocardiography. In UAPE, the number of views and interpretation are limited to only ultrasound signs suggesting cardiac disease, in contrast to a limited echocardiogram, in which the user is responsible for all diagnoses, primary and incidental, manifest in the limited number of views in the imaging protocol ( Table 16.3 ). Under these terms, the term “limited” refers to the number of views and not the number of diagnoses. Limited echocardiography is a formal medical imaging test requiring imaging standards, study archival, and an all-inclusive interpretation and report. The evolving practice of POCUS is clearly different from the current practice of limited echocardiography because no formal diagnostic medical imaging test has the potential of being applied with such repetition and frequency by multiple physicians on the same patient.

Table 16.3
Point-of-Care Ultrasound as a Physical Examination Technique Versus Limited Ultrasound Examination
POCUS as Ultrasound-Augmented Physical Exam POCUS as Limited Echocardiogram
Clinical use
  • Applied during any physical examination

  • Simplified, brief imaging protocol for “signs” of disease

  • Frequent, repeated, daily use

  • Abnormalities should prompt echo referral or consultation, time allowing

  • Applied as a diagnostic test for a single entity

  • Applied once initially but can be repeated as follow-up exam (e.g., pericardial effusion)

Indication
  • Obtaining structural data to help form clinical diagnosis

  • Screening

  • Risk stratification

  • Documentation of medical necessity

  • For diagnosis or exclusion of an entity after initial considerations

Equipment
  • Simplified, 2D imaging, limited Doppler

  • Ideally pocket sized, portable

  • Inexpensive

  • Battery powered

  • Individually owned

  • Short boot times

  • Standard echocardiograph, fully featured

  • Expensive with shared ownership or hospital ownership

  • Often connected to PACS

Accuracy
  • Moderate sensitivity and high specificity for signs related to disease

  • Early, subclinical disease often detected

  • High sensitivity and specificity for diagnosis sought by imaging protocol.

  • Can be gold standard exam

Potential liability
  • Only for signs sought

  • For all findings manifest, primary and incidental

Medicare CPT
  • As a part of Evaluation and Management codes

  • 93308

Documentation
  • As a part of physical exam in the history and physical

  • Image archival optional

  • Images archived to PACS

  • Separate formal report

Education
  • Medical school, residency

  • Subspecialty (cardiology, anesthesiology, critical care and emergency medicine)

Competency
  • User discretion, depending on personal accuracy

  • Evolving standards (ASCeXAM) within specialty

  • ASE examination

ASE, American Society of Echocardiography; CPT, Current Procedural Terminology; PACS, Picture Archiving and Communication System; 2D, two-dimensional.

Instrumentation: Form Fits Function

The form of developing POCUS equipment follows its intended function by maximizing portability and simplicity but also for documentation, limited quantitation, and connectivity. By far the most controversial development has been in pocket-sized ultrasound devices, bringing to the forefront issues of device ownership and use in the hospital—as either a personally owned ultrasound stethoscope or a hospital-purchased device with compatibility to archive studies into hospital-based systems. Currently, additional features vary by manufacturer and include color or Spectral Doppler, interchangeable or multifrequency transducers, and varying forms of image storage and transmission. Image setting presets are available to allow quick “boot-ups” for cardiac, abdominal, or obstetrics and gynecology imaging. Color or spectral Doppler gives the user the capability to differentiate an anechoic region such as a cyst as opposed to a vessel and allows a gross visual assessment of flow patterns as arterial or venous. For more advanced users, the presence of color Doppler can also be used to estimate valvular regurgitation and severity. Pulsed-wave spectral Doppler also provides the potential to assess diastolic filling patterns. Battery-life generally provides 1 to 2 hours of continuous imaging, further promoting brief quick-look application and recharging every 1 to 2 days. Remote real-time imaging with “telementoring” has already been reported as a feasible and inexpensive method for health care delivery and training.

Today, portable ultrasound devices have a wide range of cost, from $2000 for a pocket-sized device to $25,000 for a bedside tablet or laptop ultrasound device. No specific payor reimbursement exists for use of any device when used to augment bedside physical examination. However, cost savings to a health care system will be significant by improving diagnostic efficiency in outpatient echo referral, timeliness of triage, and appropriateness of consultation. For inpatients, assuming billing is performed for limited echocardiography and fully overread by a cardiologist, a preliminary reimbursement model (with application on approximately 30%–40% of medical admissions) predicted remuneration capable of funding POCUS equipment purchase and training. , Presently, partnerships, call groups, hospital departments, and clinics often share a POCUS device given the limited number of trained users.

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