Uropathology

Squamous cell carcinoma, pseudoglandular

Definition Highly aggressive squamous cell carcinoma composed of infiltrative solid tumor nests with central acantholysis as a prominent feature, simulating a glandular lumen Clinical features Epidemiology Rare, with only a few cases reported You’re Reading a Preview Become a Clinical…

Squamous cell carcinoma, pseudohyperplastic variant

Definition A well-differentiated squamous cell carcinoma (SCC) of the penis with endophytic growth that preferentially involves the foreskin and usually arises in association with lichen sclerosus Clinical features You’re Reading a Preview Become a Clinical Tree membership for Full access…

Squamous cell carcinoma, papillary

Definition A variant of squamous cell carcinoma (SCC) with verruciform growth pattern, not associated with HPV infection Clinical features Epidemiology Accounts for 5%–15% of penile SCC Affects patients in fifth and sixth decades of life Not associated with HPV infection…

Squamous cell carcinoma, verrucous

Definition A subtype of well-differentiated squamous cell carcinoma (SCC) with broad papillary fronds and pushing base; no apparent association with HPV infection Clinical features You’re Reading a Preview Become a Clinical Tree membership for Full access and enjoy Unlimited articles…

Lymphoepithelioma-like carcinoma

Definition HPV-related poorly differentiated squamous cell carcinoma morphologically similar to its nasopharyngeal counterpart, characterized by an intense inflammatory response surrounding tumor nests Clinical features Epidemiology Rare variant with only a few cases reported Associated with HPV infection; unlike its nasopharyngeal…

Clear cell squamous cell carcinoma

Definition HPV-related penile squamous cell carcinoma characterized by an aggressive clinical behavior and a clear cell morphology Clinical features Epidemiology Rare, with only a few cases reported You’re Reading a Preview Become a Clinical Tree membership for Full access and…

Squamous cell carcinoma, warty-basaloid

Definition HPV-related squamous cell carcinoma composed of variable proportions of warty and basaloid carcinomas, either separately or intermingled. Clinical features Epidemiology Relatively frequent variant, its epidemiological features similar to other HPV-related penile tumors such as pure warty and basaloid carcinomas…

Penile warty (condylomatous) carcinoma

Definition A form of squamous carcinoma with exophytic and papillomatous growth pattern resembling condylomas but with malignant cytological features Strongly associated with high-risk human papillomavirus infection Clinical features Epidemiology 5%–10% of penile carcinomas and 20%–30% verruciform tumors Most commonly involves…

Squamous cell carcinoma, papillary-basaloid

Definition HPV-related squamous cell carcinoma characterized by exophytic papillae lined by basaloid cells, a variant of basaloid carcinoma Clinical features Epidemiology Unusual tumors, with only a few reported cases Patients with invasive tumors are older compared to those with noninvasive…

Basaloid squamous cell carcinoma

Definition An aggressive variant of squamous cell carcinoma (SCC) with basaloid features; HPV-related Clinical features Epidemiology Accounts for 5%–10% of penile SCC Most patients are 50–59 years old Associated with HPV (HPV16 most common) You’re Reading a Preview Become a…