Physical Address
304 North Cardinal St.
Dorchester Center, MA 02124
Abbreviations
You’re Reading a Preview Become a Clinical Tree membership for Full access and enjoy Unlimited articles Become membership If you are a member. Log in here
Diagnostic Use of Venoms
The most common use of snake venom molecules as reagents in hemostasis is described below. Fibrinogen Assessment Fibrinogen promotes platelet aggregation and is converted to fibrin by thrombin, with formation of a hemostatic plug. Reptilase Time This is a modification…
Thrombin Generation Assays
The TGA is a global test of coagulation systems, with the potential to contribute to the current arsenal of clinical prognostication and drug monitoring tools. By varying the conditions under which it is applied, the test can be made sensitive…
Circulating Microparticles
Microparticle (MP) analysis has become popular in the last decade because of mounting evidence of their active role in multiple cellular processes. Alterations in total MP numbers or changes in the relative abundance of MP populations have been correlated with…
Molecular Testing in Coagulation
John Bartlett, Director of Diagnostic Development at the Ontario Institute for Cancer Research writes that “accurate and appropriate diagnosis is fundamental to the successful treatment of disease.” With the introduction and evolution of new technologies, we can evaluate coagulopathy at…
Laboratory Support for Warfarin Monitoring
Warfarin use has declined with increased adoption of oral direct thrombin and direct factor (F) Xa inhibitors, but warfarin remains an important oral anticoagulant for patients with contraindications to or indications not currently covered by direct oral anticoagulant therapy, and…
Laboratory Monitoring for Heparins, Fondaparinux, Direct Thrombin Inhibitors, and Oral Anti-Xa Medications
Laboratory testing modalities and recommendations for monitoring heparin, heparin-like medications, direct thrombin inhibitors (DTIs), and direct anti-Xa inhibitors (DXIs), including indications, testing recommendations, testing modalities, and test limitations are discussed below. There are several options available for laboratory monitoring of…
Laboratory Diagnosis of Lupus Anticoagulant and Antiphospholipid Antibodies
Introduction Antiphospholipid (aPL) antibodies are a heterogeneous family of autoantibodies that are primarily directed against plasma proteins complexed with anionic phospholipids that are found on damaged/activated cellular membranes, including endothelial cells, trophoblasts, platelets, and monocytes. The formation of autoantibodies against…
Laboratory Evaluation of Thrombotic Thrombocytopenic Purpura
A rapid and accurate diagnosis of thrombotic thrombocytopenic purpura (TTP) is critical, as initiation of therapeutic plasma exchange (TPE) can be lifesaving. To date, the diagnosis of TTP is dependent on the demonstration of an otherwise unexplained microangiopathic hemolytic anemia…
Laboratory Evaluation of Heparin-Induced Thrombocytopenia
Heparin-induced thrombocytopenia (HIT) is a clinicopathologic syndrome characterized by a constellation of clinical findings and identification of antiplatelet factor 4 (PF4)/heparin antibodies. Classically in HIT, progressive thrombocytopenia is observed, reaching a nadir within 5–10 days following the immunizing heparin exposure.…