Skin Disease: Diagnosis and Treatment

Premalignant and Malignant Nonmelanoma Skin Tumors

Basal Cell Carcinoma Description ■ Basal cell carcinoma is a skin cancer derived from the basal layer of keratinocytes of the epidermis. ■ It is the most common cutaneous malignancy and most common cancer in humans. ■ If left untreated,…

Benign Skin Tumors

Seborrheic Keratosis Description ■ A seborrheic keratosis is a common, benign, persistent epidermal lesion with variable clinical appearance. ■ It is one of the most common benign growths seen on the skin. ■ These keratoses have multiple clinical variations and…

Light-Related Diseases and Disorders of Pigmentation

Sun-Damaged Skin, Actinic-Damaged Skin, and Photoaging Description ■ Sun-damaged skin is easily recognizable and shows specific skin findings, resulting from damage due to ultraviolet radiation (UVR). History ■ Acute exposure to UVR results in sunburn and is especially caused by…

Connective Tissue Diseases

Lupus Erythematosus General Description ■ Cutaneous lupus erythematosus is a disease with a wide spectrum of manifestations ranging from solitary chronic skin lesions in chronic cutaneous lupus erythematosus (CCLE), to widespread polymorphous lesions in subacute cutaneous lupus erythematosus (SCLE), to…

Vesicular and Bullous Diseases

Dermatitis Herpetiformis Description ■ Dermatitis herpetiformis (DH) is a chronic pruritic vesicular rash commonly occurring on the extensor surfaces and is a manifestation of gluten sensitivity. History ■ In adults, DH is twice as common in males. ■ In children,…

Infestations and Bites

Scabies Description ■ Scabies is a parasitic infestation of the skin caused by the mite Sarcoptes scabiei var. hominis. ■ It is characterized by an intensely pruritic eruption and may be the etiology of “the 7-year itch.” History ■ Patients…

Hypersensitivity Syndromes and Vasculitis

Erythema Multiforme Description ■ Erythema multiforme is a relatively common, acute—often recurrent—inflammatory disease characterized by target-shaped skin lesions. History ■ Commonly, erythema multiforme is associated with herpes simplex, Mycoplasma pneumoniae, and upper respiratory tract infections, although erythema multiforme may be…

Exanthems and Drug Reactions

Nonspecific Viral Rash Description ■ An exanthem is a rash that occurs as a sign of a systemic disease. A viral exanthem is a rash that arises because of a viral infection. ■ Most viruses produce similar rashes, leading to…

Fungal Infections

Candidiasis (Moniliasis) Description ■ Candida albicans and a few other Candida species are capable of producing skin and mucous membrane infections. ■ The organism lives among the normal flora of the mouth, vaginal tract, and lower gastrointestinal tract. ■ Candida…

Viral Infections

Warts (Verruca Vulgaris) Description ■ Warts are benign epidermal proliferations caused by human papillomavirus (HPV) infection, a double-stranded DNA virus, which infects skin and mucous membranes. ■ There are more than 150 different types of HPV. New subtypes are defined…