See also Cytotoxic and immunosuppressant drugs General information Fluorouracil is a fluorinated pyrimidine, which is converted intracellularly to the active form, fluorodeoxyuridine monophosphate, which inhibits thymidylate synthetase and hence reduces the production of thymidylic acid, the deoxyribonucleotide of thymine (5-methyluracil),…
General information Following the introduction of the first quinolone antibiotic (nalidixic acid, see separate monograph), structural modifications to the basic quinolone and naphthyridone nucleus and to the side-chains produced fluoroquinolones with improved coverage of bacterial pathogens, with high activity against…
General information Fluoride is the single most potent bone-forming agent currently available for therapeutic use [ ]. The active moiety is the fluoride ion itself, and its main pharmacological effect is on dental enamel and bone. Fluoride ions bind to…
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See also Benzodiazepines General information Flunitrazepam has acquired a reputation for toxicity, abuse potential [ ] and associated forensic problems [ ], including being implicated in sexual assault (“date rape”) [ ]. It has been withdrawn from general availability in…
General information Flumazenil is used as a benzodiazepine antagonist in the treatment of poisoning or the reversal of benzodiazepine effects in anesthesia [ , ] or in neonates [ ]. Guidelines for its use have been summarized [ ]. The…
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See also Cytotoxic and immunosuppressant drugs General information Fludarabine phosphate is a purine nucleoside antitumor agent, which inhibits adenosine deaminase. It is mainly used to treat chronic lymphocytic leukemia. Dose-limiting myelotoxicity, nausea and vomiting, and raised liver enzymes were observed…
See also Cytotoxic and immunosuppressant drugs General information Flucytosine is an antimetabolite of the fluoropyrimidine type. The principle of selectivity of flucytosine for the fungal cell is dual: it depends on an enzyme in order to penetrate the cell (fungal…
See also Antifungal azoles [for systemic use] General information Fluconazole is an antifungal triazole that was derived from the older imidazoles. It has a lower molecular weight and is soluble in water. It can be administered orally and parenterally. Pharmacokinetics…