See also Insulin General information Insulin aspart is a rapid-acting synthetic insulin in which proline is replaced by aspartate at position 28 in the B chain. Insulin aspart has been reviewed [ ]. Its adverse effects and the resulting adverse…
See also Insulin aspart ; Insulin detemir ; Insulin glargine ; Insulin lispro General information Insulin is used for substitution therapy in patients with an absolute or relative deficiency of insulin. Most of the insulins now prescribed are either human…
General information Inosine pranobex is a synthetic product, also known as isoprinosine or inosine dimepranol acedobene, with antiviral properties that are assumed to be related to its effect on T cell-mediated immunity rather than to direct antiviral activity. It has…
General information Pulmonary delivery of drugs is the administration route of choice in respiratory diseases such as chronic obstructive pulmonary disease and asthma. Different devices are available, including metered-dose inhalers, dry powder inhalers, and nebulizers, and nearly 80% of asthmatic…
See also Vaccines General information Influenza vaccine viruses are propagated in embryonated chicken eggs. The virus-containing extra-embryonic fluid is harvested, purified, and inactivated with formalin. Inactivated flu vaccine is produced either as whole virus vaccine or ether-disrupted split or subunit…
See also Monoclonal antibodies General information Infliximab is a chimeric, human-murine anti-TNF monoclonal antibody. It was initially approved by the Food and Drug and Administration in August 1998 for the treatment of moderately to severely active Crohn’s disease [ ,…
See also Alpha-adrenoceptor antagonists General information Indoramin is a postsynaptic selective alpha 1 -adrenoceptor antagonist that is chemically distinct from the quinazolines. Unlike some other alpha-blockers, indoramin lowers blood pressure without a resulting reflex tachycardia or postural hypotension [ ].…
See also Non-steroidal anti-inflammatory drugs (NSAIDs) General information Indoprofen is one of several NSAIDs that have been withdrawn because of adverse reactions. The UK Licensing Authority suspended the product licence on grounds of safety in 1983, and in 1984 the…
See also Non-steroidal anti-inflammatory drugs (NSAIDs) General information Indometacin is the best-known and most thoroughly tested indoleacetic acid derivative. It is one of the most effective non-steroidal anti-inflammatory drugs (NSAIDs), and most of its toxic and therapeutic effects appear to…
See also HIV protease inhibitors General information Indinavir is an HIV protease inhibitor. As for most other protease inhibitors, the use of indinavir has been markedly simplified by co-administration of low-dose ritonavir, which allows indinavir to be given twice daily…