General information Repirinast is an antiallergic prodrug which is de-esterified to an active metabolite that has a stabilizing action on mast cells resembling that of sodium cromoglicate [ ]. You’re Reading a Preview Become a Clinical Tree membership for Full…
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See also Opioid receptor agonists General information Remifentanil is a pure μ opioid (OP 3 , MOR) receptor agonist with a very short duration of action. It therefore has to be given by continuous intravenous infusion and is used as…
General information Remacemide hydrochloride is a low-affinity, non-competitive N-methyl- d -aspartate (NMDA) receptor blocker that has been used in epilepsy, Parkinson's disease, Huntington's chorea [ ], and neuroprotection after stroke [ ]. Its pharmacology, clinical pharmacology, uses, and adverse reactions…
General information Reboxetine is a selective noradrenaline re-uptake inhibitor with low affinity for α-adrenoceptors and muscarinic receptors [ ]. In controlled trials the following adverse events occurred significantly more often with reboxetine than with placebo: dry mouth (27%), constipation (17%),…
General information Razaxaban, a selective oral direct factor Xa inhibitor [ , ], was discontinued by the manufacturer after the three higher doses in a dose-ranging study in venous thromboembolism caused an increased risk of bleeding. You’re Reading a Preview…
See also Antifungal azoles [for systemic use] General information Ravuconazole is an antifungal azole, similar in structure to fluconazole. It has a long half-life suitable for once-daily dosing. You’re Reading a Preview Become a Clinical Tree membership for Full access…
General information Rasburicase is recombinant urate oxidase, which causes the breakdown of uric acid to 5-hydroxyisourate, which is further broken down to allantoin. Although there is a gene for urate oxidase in human, it is non-functional, and purine catabolism therefore…
General information Rasagiline is a propargylamine that irreversibly and selectively inhibits monoamine oxidase type B and is 5–10 times more potent than selegiline. Its pharmacology, clinical pharmacology, clinical efficacy, and adverse reactions have been reviewed [ , ]. Rasagiline is…
General information Rapacuronium, an aminosteroid non-depolarizing neuromuscular blocking agent with a rapid onset and a comparatively short duration of action [ , ], was withdrawn from the US market in March 2001 and subsequently worldwide. The manufacturers informed the FDA…