Massachusetts General Hospital Comprehensive Clinical Psychiatry

The Suicidal Patient

Key Points Suicide, or intentional self-harm with the intent of causing death, is one of the most common causes of death in the US. For every completed suicide, between 8 and 25 attempts are made. Psychiatric illness is the most…

Natural Medications in Psychiatry

Key Points Complementary and alternative medical therapies are made up of a diverse spectrum of practices (including natural medications) that often overlap with more traditional medical practice. The use of natural medications is growing considerably in the US and around…

Side Effects of Psychotropic Medications

Key Points Background A systematic approach to side effects of medications should include consideration of the nature, severity, and timing of symptoms to facilitate optimal management of such side effects. History Many medications (e.g., nefazodone) previously used in psychiatric disorders,…

Drug–Drug Interactions in Psychopharmacology

Key Points Drug–drug interactions refer to alterations in drug levels or drug effects (or both) related to the administration of two or more prescribed, recreational, or over-the-counter agents in close temporal proximity. Although some drug–drug interactions involving psychotropic medications are…

The Use of Antiepileptic Drugs in Psychiatry

Key Points A “kindling hypothesis” of mood instability led to the search for anticonvulsant medications that might improve the course of illness in bipolar disorder (BPD). Divalproex sodium (valproate) and carbamazepine (in extended-release form) are effective in the treatment of…

Lithium and Its Role in Psychiatry

Key Points Lithium remains a first-line treatment for all phases of bipolar disorder, including mania, depression, and prevention of recurrence. While not examined in a controlled trial, abundant evidence supports a role for lithium in decreasing the risk of suicide.…

Neurotherapeutics

Key Points Somatic therapies are a group of device-based techniques that modulate disease-relevant structures of the nervous system via surgical ablation or electrical stimulation with the goal of therapeutically modifying pathological patterns of brain activity and circuit connectivity. Ablative limbic…

Electroconvulsive Therapy

Key Points Remission rates of 70%–90% have been reported in clinical trials of electroconvulsive therapy (ECT) and ECT is currently the most promising prospect for addressing the unmet worldwide need for effective treatment of individuals suffering from depression. The symptoms…