Key Points Incidence The age-adjusted incidence of mycosis fungoides (MF) is approximately 6.4 cases per million. Three thousand cases per year are diagnosed in the United States, representing 72% of cutaneous T-cell lymphomas. Biologic Characteristics Mycosis fungoides is a chronic…
Key Points Incidence and Epidemiology More than 32,100 new cases of multiple myeloma (MM) are diagnosed annually in the United States. MM accounts for 1.8% of all new cancers and 2.1% of cancer-related deaths. The rate in blacks is twice…
Key Points Epidemiology and Incidence There were an estimated 74,680 new cases of lymphoma and 19,910 deaths in the United States in 2018. The incidence is increasing in many countries, including the United States. The most common types are diffuse…
Key Points Incidence There are approximately 8500 new cases of Hodgkin lymphoma in the United States each year. Biological Characteristics Hodgkin/Reed-Sternberg (HRS) cells are the malignant cells in Hodgkin lymphoma. Increasing epidemiological and molecular evidence supports that a combination of…
Basic Issues in Lymphoma Significant progress has been made in recent years in the understanding of the molecular basis of lymphomagenesis, and in the diagnosis, staging, treatment, and follow-up of patients with lymphoid malignancies. The current pathological classification incorporates molecular…
Key Points Incidence (1) Hepatic tumors: 1.6 per million; male predominance. (2) Juvenile nasopharyngeal angiofibroma: 0.05% of head and neck tumors. (3) Pleuropulmonary blastoma: Extremely rare. (4) Hemangioma/lymphangioma: Hemangiomas: 1% of infants; lymphangiomas: 0.01% of infants. (5) Desmoplastic small round…
Key Points Epidemiology and Biological Characteristics Relative to adult Hodgkin lymphoma, pediatric Hodgkin lymphoma has (1) Distinct features in relation to geographic distribution, gender, association with Epstein-Barr virus (EBV), and histological subtype; (2) Relatively higher incidence in developing countries and…
Key Points Epidemiology Acute leukemias (acute lymphoblastic leukemia [ALL] and acute myeloid leukemia [AML]) and lymphomas (Hodgkin and non-Hodgkin lymphoma [NHL]) together represent approximately 40% of malignancies in children. Annual incidence of new cases in the United States in children…
Key Points Epidemiology Neuroblastoma comprises 8% to 10% of childhood cancers, with 650 cases reported annually in the United States. It is the most common extracranial solid tumor in children and the most common malignancy in infants. The tumor primarily…
Key Points Incidence Retinoblastoma accounts for 2.5% to 4% of all pediatric malignancies. Its incidence is two to five cases per million children per year amounting to approximately 300 new cases per year in the United States. Biologic Characteristics Retinoblastoma…