Risk Classically affects infants and children (80% manifest before 10 y old), but can affect any age group. No predilection for males or females. Worry About Restrictive lung disease Pulm Htn Cor pulmonale Alveolar hemorrhage Increased need for transfusion secondary…
Risk Incidence of hemophilia A, factor VIII (FVIII) deficiency is 1:5000 male births; for hemophilia B, factor IX (FIX, Christmas disease) deficiency, it is 1:25,000 male births. Number of people affected with hemophilia in USA is estimated at approximately 20,000.…
Risk Incidence of primary (hereditary) hemochromatosis: In some Caucasian populations, 10% are heterozygous carriers and 0.25–1% homozygous. Age: Clinical manifestations typically occur after age 40 in men and later in women due to the protective effect of menses. Perioperative Risks…
Risk Occurs in 0.1–0.9% of all pregnancies. Previous history of preeclampsia or HELLP syndrome is a risk factor for HELLP. Occurs in 10–20% of women suffering from preeclampsia with severe features. May be a form of preeclampsia. Preeclampsia occurs in…
Risk CHD is the most common birth defect. Incidence: 1:25 live births. 85–90% of pts with CHD survive to adulthood in USA due to advances in medical care. Perioperative Risks The highest risk factors of this complex disease include HLHS;…
Risk Incidence in USA: >28 million; maximum prevalence is in 25–55 y of age. Can start as early as 1 y of age; 10–20% of instances occur in children by 20 y of age, with males and females being equally…
Risk Hashimoto thyroiditis is the most common cause of hypothyroidism in iodine-sufficient countries and primary hypothyroidism in adults. Incidence in USA: Approximately 100,000–400,000 new cases diagnosed each year. Causes thyroid failure in 10% of pts. Prevalence increases with age but…
Risk Occurs in both sexes, all races, all ages, but mostly affects young and middle-aged adults. Worldwide illness and occurs at all times of the year. Mortality rate is 3–7%; most pts eventually fully recover and 20% have significant residual…
Risk Incidence: Approximately 5:10,000; prevalence: 1.12%, with 1.3 million pts in USA. Female-to-male ratio: 7:1; more common in women age 30–60 y. Family history indicating genetic factor(s) can be involved. Perioperative Risks “Thyroid storm” due to surge of plasma thyroid…
Risk Overall incidence: 0.05% in the USA population Most common inflammatory joint disease among men Associated with nephropathy, most commonly nephrolithiasis (10–40% of pts) Also associated with CV disease, specifically an increased risk of myocardial infarction, but also including heart…