Diastology

Physical Determinants of Diastolic Flow

Comprehensive assessment of ventricular diastolic function is a complex process. Full elucidation generally requires invasive measurements, such as left ventricular end-diastolic pressure (EDP), the time constant of isovolumic left ventricular (LV) relaxation (τ), the pressure-volume (P-V) relationship of the ventricle…

Left Atrial Function: Basic Physiology

Case Study DL is a 75-year-old white male with a history of hypertension who presented with a 6-month history of reduced exercise tolerance, dyspnea on exertion, and occasional palpitations. The patient was scheduled for an exercise test but was noted…

Role of the Pericardium in Diastolic Dysfunction

Introduction Pericardial diseases are often underdiagnosed and confused with other pathologic entities such as chronic liver diseases, heart failure, and restrictive cardiomyopathies especially in the setting of complicated pericarditis with evolution to constrictive pericarditis. The main reasons for these misunderstandings…

Molecular, Gene, and Cellular Mechanism

Although heart failure (HF) has been traditionally affiliated with reduced contractile function and dilation of the left ventricle (LV) resulting in reduced ejection fraction (HFrEF), nearly half of HF patients have an ejection fraction that is normal. These patients present…