Summary of Key Points Definition Adult T-cell leukemia/lymphoma (ATLL) is a distinct mature peripheral T-cell malignancy associated with human T-cell leukemia/lymphotropic virus type I (HTLV-I). Virology and Pathogenesis HTLV-I is reverse-transcribed into DNA and randomly integrated into the host cell.…
Summary of Key Points Incidence Cutaneous lymphomas represent 3.9% of non-Hodgkin lymphomas. The annual incidence of cutaneous T-cell lymphoma (CTCL) in the United States is approximately 9.6 cases per 1 million population with a median age of 60 years at…
Summary of Key Points Incidence Non-Hodgkin lymphoma (NHL) is the most common hematologic malignancy; more than 70,000 cases were estimated to be diagnosed in the United States in 2018. Diffuse large B-cell (DLBCL) and follicular lymphoma (FL) are the most…
Summary of Key Points Incidence There were an estimated 8260 new cases of Hodgkin lymphoma (HL) in the United States in 2017 with 1070 deaths. The US age-adjusted incidence rate is 2.6 per 100,000 per year. There is a higher…
Summary of Key Points Multiple Myeloma Multiple myeloma accounts for approximately 10% of hematologic malignancies. Approximately 30,000 new cases are estimated to occur each year in the United States. In almost all patients, multiple myeloma is thought to evolve from…
Summary of Key Points Classic hairy cell leukemia and hairy cell leukemia variant are rare clonal B-cell lymphoproliferative disorders. The BRAF V600E mutation is present in nearly all cases of classic hairy cell leukemia but absent in other B-cell lymphoproliferative…
Summary of Key Points Chronic lymphocytic leukemia (CLL) is the most prevalent type of adult leukemia and is defined by a distinctive immunophenotype of CD19+, CD5+, CD23+, and surface immunoglobulin (sIg)–positive cells. The environmental or genetic cause of CLL in…
Summary of Key Points Incidence The incidence of chronic myeloid leukemia (CML) is 1.5 in 10 5 , about 5000 cases per year in the United States; CML represents 15% of all leukemias. The prevalence of CML was 30,000 cases…
Summary of Key Points Incidence Each of the three classic BCR-ABL1 − myeloproliferative neoplasms (MPNs)—that is, polycythemia vera (PV), essential thrombocythemia (ET), and primary myelofibrosis (PMF)—are estimated to occur at the rate of 0.5 to 2.5 per 100,000 people per…
Summary of Key Points Etiology The myelodysplastic syndromes (MDS) are a group of clonal marrow failure syndromes originating in a hematopoietic progenitor or stem cell. Approximately 25% to 30% of MDS cases eventually progress to acute myeloid leukemia (AML), which…