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Flurbiprofen
See also Non-steroidal anti-inflammatory drugs (NSAIDs)
General information
In a short-term multicenter study of flurbiprofen only 6% of patients were withdrawn because of adverse reactions [ ]. However, in a prolonged open study in 1200 patients, more than 50% reported adverse reactions and therapy had to be withdrawn in l9% [ ].
Organs and systems
Nervous system
Nervous system reactions to flurbiprofen are less common than with indometacin [ ]. Flurbiprofen precipitates extrapyramidal reactions, albeit rarely [ ], and a parkinsonian syndrome has been reported in a predisposed patient [ ].
Gastrointestinal
Flurbiprofen causes more gastrointestinal adverse reactions than naproxen or ibuprofen. In a series of controlled double-blind studies, adverse reactions occurred in 27–42% of patients and were most commonly gastrointestinal in origin (18–28%) [ , ].
Local tolerance of flurbiprofen suppositories is often satisfactory, but discomfort, irritation, tenesmus, and diarrhea have been observed [ ].
Urinary tract
Interstitial nephritis with the nephrotic syndrome and one case of renal papillary necrosis have been recorded [ , ]. Flurbiprofen can cause a membranous nephropathy [ ].
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