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Fexofenadine
See also Antihistamines
General information
Fexofenadine is the active metabolite of terfenadine. It has antihistaminic but not dysrhythmogenic properties. It is not metabolized by the liver, but eliminated unchanged in the urine. It is efficacious and well tolerated in seasonal allergic rhinitis [ ], with positive effects on nasal blockade [ ], and in chronic idiopathic urticaria [ , ].
Drug studies
Systematic reviews
Fexofenadine can be combined with a decongestant (fexofenadine 60 mg + pseudoephedrine hydrochloride 120 mg) to provide relief from nasal blockade [ ]. In a pooled analysis of two randomized, double-blind, placebo-controlled, parallel-group allergen exposure unit studies using subjects with moderate to severe allergic rhinitis, fexofenadine + pseudoephedrine hydrochloride had a rapid onset of action (45 minutes) with a significant positive clinical effect during the 6-hour study period [ ]. The main adverse reaction was somnolence, which was not considered significant, as this adverse event was comparable in both active and placebo groups.
Organs and systems
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