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Duloxetine
General information
Duloxetine is an antidepressant that inhibits the reuptake of both serotonin (5HT) and noradrenaline [ ].
Drug studies
Placebo-controlled studies
In a placebo-controlled study of 1491 patients nausea was more frequent in those who took duloxetine (30% versus 7.1%) and weight loss was significantly greater; all of those who withdrew because of an adverse event were taking duloxetine (22%) [ ].
Systematic reviews
In a systematic review of 36 experimental and observational studies duloxetine caused nausea, vomiting, and dry mouth more often than comparator drugs, but these differences did not lead to higher withdrawal rates than in patients taking SSRIs [ ].
Organs and systems
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