Diazoxide

General information

Diazoxide is a direct vasodilator that acts on vascular smooth muscle to produce systemic vasodilatation. As a result there is baroreceptor-mediated activation of the sympathetic nervous system and the renin–angiotensin system.

Vasodilators (as monotherapy) are associated acutely with flushing, headache, dizziness, reflex tachycardia, and palpitation. Chronic treatment can be complicated by fluid retention.

Organs and systems