Cyanoacrylates

General information

Cyanoacrylate (Histoacryl) is a tissue adhesive used in duraplasty. The sites at which it is used should be carefully chosen. Its adverse effects and reactions to it have been reviewed [ ].

Cyanoacrylates are also in use for embolization of arteriovenous malformations in the brain. The risk of this procedure is the creation of pulmonary emboli after acrylate glue injection, particularly when delivery systems without flow arrest are used in high-flow vascular brain lesions. Techniques using acetic acid to delay polymerization time and “sandwich” techniques, in which glue is pushed with dextrose, appear to be more likely to cause this complication [ ].

After use as tissue adhesives cyanoacrylates can cause inflammation and tissue necrosis [ , ].

Organs and systems