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Asparaginase
General information
Asparaginase is an enzyme that acts by breaking down the amino acid L-asparagine to aspartic acid and ammonia. It interferes with the growth of malignant cells that cannot synthesize L-asparagine. Its action is reportedly specific for the G1 phase of the cell cycle. It is used mainly for the induction of remissions in acute lymphoblastic leukemia.
Nomenclature
Colaspase and crisantaspase are the British Approved Names of asparaginase obtained from cultures of Escherichia coli and Erwinia carotovora respectively.
Organs and systems
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