Reye Syndrome


Risk

  • Incidence prior to 1990: 0.3–0.6:100,000.

  • From 1987 to 1993: 0.03-0.06:100,000; 2 cases/y have been reported since 1994.

  • During early 1980s, an association between aspirin and Reye syndrome was recognized; thereafter, incidence declined dramatically. In 1986, a warning label on all aspirin-containing products was mandated in USA.

Perioperative Risks

  • Surgery (all but life-or-death emergencies) contraindicated during Reye syndrome.

  • Following recovery, LFTs must be repeated.

Worry About

  • Unrecognized inborn errors of metabolism that produce Reye-like syndromes, such as fatty-acid oxidation defects, carnitine deficiency, and amino and organic acidopathies

  • Recurrent liver dysfunction

  • Permanent neurologic sequelae

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