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Eosinophilic solid cystic renal cell carcinoma
Definition
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A recently described variant of renal cell carcinoma (RCC) defined morphologically by solid and cystic areas composed of tumor cells with voluminous eosinophilic cytoplasm and basophilic coarse cytoplasmic granules and positive cytokeratin 20 staining
Clinical features
Epidemiology
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Incidence currently unknown but rare; many were diagnosed as “unclassified RCC” or “unclassified renal oncocytic tumors”
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~10% occur in patients with tuberous sclerosis complex (TSC); majority sporadic
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Mean age: 55 (range, 32–79) years
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Female predilection with only rare cases reported in men
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