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Vulvar Squamous Carcinoma: Keratinizing Pattern
D efinition —Invasive epithelial neoplasm composed of keratinocytes involving the vulva. Human papillomavirus (HPV) negative.
Clinical Features
Epidemiology
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Typically affects women in their seventh and eighth decades and is usually found associated with inflammatory dermatosis (differentiated vulvar intraepithelial neoplasia [VIN]).
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Some patients present with no history of vulvar neoplasia.
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Not associated with HPV and not associated with squamous neoplasms of the cervix.
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