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Vulvar Squamous Carcinoma: Basaloid and Warty Patterns
D efinition —Invasive epithelial neoplasm composed of keratinocytes involving the vulva. Comprise tumors associated with classic vulvar intraepithelial neoplasia (VIN).
Clinical Features
Epidemiology
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Typically affects women in their sixth decade but can be seen in women under 40 who are immunocompromised.
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Strong association with human papillomavirus (HPV), particularly HPV 16.
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Usually found associated with classic VIN.
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Some patients present with no history of vulvar neoplasia.
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Strong association with smoking.
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Association with other lesions in the lower genital tract (cervix, vagina).
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Risk increases with increasing age.
Presentation
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May be seen in the clinical context of classic VIN symptoms (pruritus, pain, or bleeding).
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Will often complicate VIN in women aged over 50.
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