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Therapeutic thrombocytapheresis (or commonly referred to as plateletpheresis or platelet depletion) is used in primary and sometimes secondary thrombocytosis to rapidly remove platelets for prevention or treatment of hemorrhage and/or thrombosis. Reduction of platelet count achieved by this procedure is short-lived; thus, other definitive and longer-term therapies are also needed.
1.5–2 total blood volumes (TBVs) are typically processed, resulting in approximately 30%–60% reductions in platelet count.
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