Key Points As a result of the vast progress that has been made very recently in sequencing the entire human genome and in illuminating pathways that are involved in tumorigenesis, it has become clear that the malfunctioning of mutant proteins…
Key Points This chapter discusses the use of proteins, whose serum levels are often elevated in patients with malignancies, in the diagnosis and management of cancer. Many of these are so-called oncofetal antigens —that is, proteins that are expressed in…
Key Points The liver is composed of three systems: the hepatocyte, concerned with metabolic reactions, macromolecular (especially protein) synthesis, and degradation and metabolism of xenobiotics (e.g., drugs); the biliary system, involved with the metabolism of bilirubin and bile salts; and…