Tag Warren T. Goodman

Dermatology

Histiocytoses

Overview The histiocytoses represent a group of proliferative disorders that share a common CD34 + progenitor cell in the bone marrow. Three “histiocytes” of cutaneous importance are: (1) the Langerhans cell , which migrates to and from the epidermis and…

Dermatology
September 13, 2023

Dermatology

Cutaneous Manifestations of the Histiocytoses

Key Points Langerhans cell histiocytosis (LCH) is a clonal neoplastic disorder. LCH represents a spectrum of disease from asymptomatic skin-limited self-resolving lesions to systemic multisystem disease with high mortality. The majority of LCH cases harbor the BRAF V600E mutation, suggesting…

Dermatological Signs of Systemic Disease
September 12, 2023