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Acknowledgments This work was supported by grants from the National Institutes of Health to P.T.R. (R01 NS084941) and to T.P.D. (R01 NS42652 and R01 DA11271). Introduction The blood–brain barrier (BBB) is an essential physical and biochemical barrier that separates the…
Introduction The blood–brain barrier (BBB) serves to limit the exposure of the brain parenchyma to foreign substances. Early experiments illustrate the “barrier” function present in the neurovasculature, as tracers such as peroxidase injected systemically are confined to vessel lumens or…