Lambert-Eaton Myasthenic Syndrome Clinical Vignette A 61-year-old woman with no remarkable past medical history developed, over a few months, weakness of her legs with difficulty getting in and out of chairs and climbing stairs. She also experienced significant fatigue. This…
Clinical Vignette A 65-year-old previously healthy man presented to the emergency department for several months of progressive upper extremity weakness and blurry vision. He reports that over the past 3 months, playing the violin and mowing the lawn have become…
Diagnostic Approach Clinical Vignette A 65-year-old man developed a tingling sensation in the toes, which quickly gave way to painful numbness. Over the next few months, paresthesias ascended to involve his distal thighs and fingertips. Within 6 months, he required…
Clinical Vignette A 48-year-old hospital administrator began having difficulties during meetings when her back would stiffen up every time she was asked to get up to speak. Subsequently, she developed episodes of anxiety accompanied by her left leg tightening up.…
Clinical Vignette A 54-year-old man developed acute-onset right thigh, hip, and buttock pain. He reported right knee “buckling” when he stepped off a curb, resulting in a fall. He also noted right foot drop. Paresthesias developed over the right thigh,…