Introduction and Historical Background The classification of malignant lymphomas has undergone significant changes over the past 50 years. The current approach is based on the integration of morphologic, phenotypic, genetic, and clinical features that allows the identification of distinct disease…
Human primary immunodeficiencies (PIDs) are inborn errors of the immune system and comprise over 260 different genetic disorders. PIDs often result in predisposition to infection and tend to present early in life, with high morbidity and high mortality if left…
The spectrum of virally associated B-cell lymphoproliferative diseases is broad, ranging from reactive lymphadenitis to lymphomas. Often the reactive processes can be diagnostically challenging and mimic lymphomas due to a combination of direct viral effects and indirect ones mediated by…
Perhaps in no other subspecialty of pathology does immunohistochemistry (IHC) play as important a role in the accurate diagnosis and definition of disease subtypes as it does in hematopathology. Before the development of this technology, the diagnosis of lymphoproliferative diseases…