Editors' comment: The short-term maternal and offspring effects of preeclampsia are presented in Chapter 2. This is a new chapter to the fifth edition of Chesley's Hypertensive Disorders in Pregnancy, focusing on long-term health. The topic of remote maternal health…
Editors' comment : The role of the renin–angiotensin–aldosterone system (RAAS) in preeclampsia has intrigued investigators for decades. Chesley had a chapter devoted to this topic in his first edition, and he would have been delighted by some of the novel…
Editors' comment: In the chapter entitled “Metabolic syndrome and preeclampsia” of the previous (fourth) edition of this textbook, we advanced the concept that components of metabolic syndrome interact with placental factors to promote inflammation, endothelial cell dysfunction, and the maternal…
Editors' comment : It was not until the early 1980s that physicians and scientists gained an appreciation of the physiological importance of the endothelium, the simple unicellular layer lining the luminal surface of blood vessels. Indeed, in Chesley's first, single-authored…
Acknowledgments MV is grateful to Drs. William Cooke, Sofia Cerdeira, and Neva Kandzija for their helpful contributions to this chapter. CR acknowledges the major contributions from Ian Sargent, who developed the STBEV story in Oxford. Editors' comment: This is a…
Editors ' comment: When Leon Chesley's Hypertensive Disorders in Pregnancy was initially published in 1978 , as now, hypertension complicating pregnancy was a major cause of fetal and maternal morbidity and death. Most of this morbidity was and remains associated…