Myelodysplastic syndrome (MDS)/myeloproliferative neoplasm (MPN) overlap syndromes are a group of rare myeloid malignancies that paradoxically exhibit both dysplastic and proliferative hematopoietic cell characteristics. They share phenotypic features of both MDS, such as dysplasia and cytopenias, and of MPNs, including…
Primary myelofibrosis (PMF) is a Philadelphia chromosome-negative, clonal, myeloproliferative neoplasm (MPN) that is often but not always accompanied by the driver mutations JAK2V617F , calreticulin exon 9 ( CALR ), and the thrombopoietin receptor, MPL515L/K . PMF is clinically characterized…
Myelodysplastic syndrome (MDS)/myeloproliferative neoplasm (MPN) overlap syndromes are a group of rare myeloid malignancies that paradoxically exhibit both dysplastic and proliferative hematopoietic cell characteristics. They share phenotypic features of both MDS, such as dysplasia and cytopenias, and of MPNs, including…
Primary myelofibrosis (PMF) is a Philadelphia chromosome-negative, clonal, myeloproliferative neoplasm (MPN) that is often but not always accompanied by the driver mutations JAK2V617F , calreticulin exon 9 ( CALR ), and the thrombopoietin receptor, MPL515L/K . PMF is clinically characterized…
A Brief Overview of Acute Myeloid Leukemia Acute myeloid leukemia (AML) is understood to be the product of genetic and epigenetic changes within a multipotent myeloid stem/progenitor cell that generate and amplify a clone capable of differentiation arrest and uncontrolled…
General Overview Myelodysplastic syndromes (MDSs) represent a heterogeneous group of myeloid neoplasms characterized by abnormal differentiation and maturation of myeloid cells, ineffective hematopoiesis, and increased risk of transformation to acute myeloid leukemia (AML). Peripheral blood (PB) cytopenias are common, with…