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Introduction Historical Background The history of mitochondria can be traced back at least to 1850 when Kolliker described a regular array of subcellular particles in muscle sarcomeres. Fifty-two years were to pass before Luft and colleagues implicated mitochondria as the…
Introduction and Background Metabolic myopathies are clinical disorders in which defects of adenosine triphosphate (ATP) production cause muscle dysfunction. A review of muscle metabolism is beyond the scope of this chapter and readers are referred to other reviews for further…