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The atrioventricular (AV) node is the only connection between the atria and ventricles in the normal heart. It modulates the AV conduction to provide enough delay between atrial and ventricular conduction to allow for ventricular filling. In addition, its decremental…

Acknowledgments This work is supported in part by grants from the US Public Health Service (HL133127, HL108037, and HL081707) and the American Heart Association (18SFRN34230125). Introduction A major challenge in prescribing antiarrhythmic drugs is the occurrence of drug-induced ventricular arrhythmias…