The myelodysplastic syndromes (MDS) are a set of diseases characterized by progressive peripheral cytopenias and dysplastic morphology of hematopoietic cells. MDS affects predominantly the elderly, but it can occur throughout life, including in childhood. MDS is a clonal hematopoietic neoplasm…
Definition of Disease and Nomenclature Hairy cell leukemia (HCL) is a mature B-cell neoplasm that involves primarily the blood, bone marrow, and splenic red pulp. The neoplastic lymphocytes have surface “hairy” projections and express the B-cell–associated antigens CD19, CD20, and…
The bone marrow and spleen may be affected by a wide variety of infectious agents. Pathologists must be aware of the clinical concern for infection to initiate appropriate studies to detect microorganisms and be prepared to recognize features of infection…