Key Points Leukocytes are regulated by complex homeostatic mechanisms that direct their responses to infection and inflammation. Leukocytosis often reflects an underlying abnormality; leukopenia, especially neutropenia, places a patient at risk for infection. Hematopoietic neoplasms have been categorized by a…
Key Points Hematopoietic stem cells are a rare population of cells in the adult bone marrow that sustains hematopoiesis and gives rise to all kinds of blood cells, including granulocytes, monocytes, lymphocytes, megakaryocytes, and erythrocytes. Differentiation and maturation of hematopoietic…
Definition The bone marrow, the primary site of hematopoiesis, may contain hematopoietic or non-hematopoietic tumors and also frequently reflects metabolic disturbances. The occurrence of bone marrow metastases is strongly influenced by microenvironmental factors that favor the engraftment of certain malignancies.…