Key Concepts Radiofrequency ablation, particularly pallidotomy, thalamotomy, and subthalamotomy, has been an effective surgical option for symptomatic relief of Parkinson disease for over 80 years. Ablation is particularly useful in patients for whom implanted hardware is contraindicated (e.g., infection risk,…
Disclosure Dr. Gross serves as a consultant to Medtronic and NeuroPace, Inc., and receives compensation for these services. Medtronic and NeuroPace develop products related to the research described in this chapter. The terms of this arrangement have been reviewed and…
Introduction Overview of MDD Major depressive disorder (MDD) is a common psychiatric complaint with a lifetime prevalence of 17% ( ), affecting some 5% of the world’s population at any given time ( ). It is characterized by one or…
Introduction Optogenetics is defined as the use of light-based technologies that are genetically targeted to certain cellular groups or proteins ( ). In practice, optogenetics most often refers to the use of genetically modified, microbial rhodopsins (pigmented light-sensitive membrane proteins)…