Key points Epidemiological studies show that the incidence of gastroparesis in women is four times higher than men. Female sex hormones fluctuate during different hormonal stages including the menstrual cycle, pregnancy, and menopause raising the theory that differences in gonadal…
Introduction The sine qua non of gastroparesis is delayed gastric emptying but as currently defined, gastroparesis is likely a heterogeneous disorder in which symptom pathogenesis is triggered by multiple discrete and connected mechanisms, with delayed gastric emptying representing an epiphenomenon…
Introduction The NIH Gastroparesis Clinical Research Consortium (GpCRC) was started in 2005 to improve the understanding of the pathogenesis and natural history of gastroparesis of all etiologies and to advance the diagnosis and therapy of patients affected with this troubling…
Introduction Gastroparesis (GP) is a disorder of delayed gastric emptying in the absence of mechanical obstruction that manifests with abdominal pain, nausea/vomiting, bloating and early satiety. Total or subtotal gastrectomy is indicated only as the final step in the GP…
Although nausea, vomiting, early satiety, and postprandial fullness are the main symptoms of gastroparesis, abdominal pain can be a prominent symptom in some patients with gastroparesis. Treatment of abdominal pain in patients with gastroparesis can be particularly difficult, as often…
Gastroparesis is a heterogeneous syndrome with variable clinical manifestations. Some patients present with regurgitation-predominant symptoms suggestive of gastroesophageal reflux disease, but effortless regurgitation of undigested foods after meals and at night should suggest gastroparesis . Other patients may have prominent…
Introduction Idiopathic gastroparesis (IG) is defined as delayed gastric emptying with associated symptoms thereof without an identifiable cause. Although more than 90 possible causes of gastroparesis have been identified in the literature including case reports, the most common subsets are…
Introduction Gastroparesis is defined as slow emptying of the stomach with associated symptoms thereof in the absence of mechanical obstruction . Symptoms can vary but are focused on the postprandial time period and include fullness, bloating, early satiety, nausea, epigastric…
Introduction Remarkable progress has been made in the study of gastrointestinal (GI) motility, particularly gastric motility, in the last century. This progress in GI motility has proceeded from contributions of a wide range of disciplines with advances in smooth-muscle physiology,…
Introduction The word gastroparesis is derived from the Greek words gastro and pa'resis, and translates to partial paralysis of the stomach. The diagnosis of gastroparesis is defined as delayed gastric emptying in the absence of mechanical obstruction, associated with one…