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Acute kidney injury (AKI) is a common and serious condition, the diagnosis of which depends on serum creatinine measurements. Unfortunately, creatinine is a delayed and unreliable biomarker of AKI. The lack of reliable early biomarkers has crippled our ability to…
Objectives This chapter will: 1. Describe cellular and molecular mechanisms at the base of acute kidney injury pathophysiology. 2. Detail alterations occurring at genetic, histologic, tubular, glomerular, and vascular levels. 3. Describe the role of nephrotoxins, inflammation, and organ cross-talk…