INTRODUCTION A preponderance of clinical and experimental evidence suggests that systemic inflammation and its neurobiological consequences are involved importantly in brain injury and subsequent impairments of brain maturation in both term and preterm newborns, The central nervous system (CNS) is…
Brain injury in the premature infant is composed of multiple lesions, traditionally described as germinal matrix intraventricular hemorrhage (IVH) with or without parenchymal involvement, posthemorrhagic hydrocephalus (PHH), and periventricular leukomalacia (PVL). These mostly focal lesions mainly affecting white matter have,…
Normal development of the human central nervous system (CNS) encompasses several steps, including neuroectoderm induction, neurulation, cell proliferation and migration, programmed cell death, neurogenesis and elimination of excess neurons, synaptogenesis, stabilization and elimination of synapses, gliogenesis, and myelination ( Table…
Key Points The brain of the preterm and term newborn infant is actively developing, with several key steps occurring during the third trimester, such as the end of neuronal migration, programmed cell death, the generation of axons and dendrites, and…