Philipp Lirk Archives - Clinical Tree

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Historical Perspective Cocaine, the first local anesthetic, was isolated from leaves of the coca plant, Erythroxylum coca, by Albert Niemann in 1860. The medicinal use of coca had long been a tradition of Andean cultures but it was only after…

Local Anesthetics

Key Points ▪ Local anesthetics block voltage-gated sodium channels and thereby interrupt initiation and propagation of impulses in axons, but they have a wide variety of other biologic actions, desirable and undesirable. ▪ Currently available local anesthetics are of two…