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Key Points Solid-tissue (predominantly epithelial cell) tumors are mainly caused by genetic lesions of three types: deletion or inactivation of tumor suppressor genes, mutation in or overexpression of oncogenes (i.e., genes encoding proteins that are vital in control of the…
Key Points This chapter discusses the use of proteins, whose serum levels are often elevated in patients with malignancies, in the diagnosis and management of cancer. Many of these are so-called oncofetal antigens —that is, proteins that are expressed in…