Tag Mindy S. Lo

Childhood-onset disease represents a substantial portion of systemic lupus erythematosus (SLE). Although pathophysiology, disease manifestations, and treatment strategies are generally similar to those of adult patients, there are some unique considerations in the diagnosis and management of pediatric lupus. Epidemiology…

Introduction The genetic origins of lupus, as reviewed in chapter, Genes and Genetics in Human Systemic Lupus Erythematosus, are extraordinarily complex. Variants in several dozen immune pathway genes are known to contribute to the pathophysiology of SLE. These variants are…