D efinition — A low-grade neoplasm that is thought to arise in the mesonephric remnants of the broad ligament. Clinical Features Epidemiology Female adnexal tumors of (probable) wolffian origin (FATWOs) are rare neoplasms, and no clinical or demographic associations have…
D efinition — Intraepithelial neoplasms of presumed nontubal origin. Clinical Features Epidemiology Uncommon but a function of the thoroughness to which the tube is examined. Can be seen with both gynecologic and nongynecologic tumors. Mucosal involvement will be seen in…
D efinition — Adenocarcinoma arising in the tubal mucosa. Clinical Features Epidemiology Historically a small fraction (5% or less) of pelvic serous carcinomas relative to the ovary; however, with the attention being paid to the distal tube (using the section…
D efinition — Psammous calcifications in the lumen and plica of the fallopian tube. Clinical Features Epidemiology Uncommon. Approximately one half are associated with low-grade serous tumors of the ovary (borderline or low-grade malignancies). You’re Reading a Preview Become a…
D efinition — A procedure designed to remove the tubes and ovaries prior to the development of malignancy in women at high risk for ovarian cancer (BRCA1/2 germ-line mutations). Clinical Features Epidemiology Heterozygous germ-line mutations in BRCA1 or BRCA2 occur…
D efinition — Intramucosal (noninvasive) serous carcinoma. Undisputable origin of pelvic serous cancer when found in isolation or with early invasion. A plausible candidate of origin when found in association with advanced disease. Clinical Features Epidemiology Serous tubal intraepithelial carcinoma…
D efinition — An increase in thickness of the epithelial layer, occasionally forming papillary tufts within the tubal lumen. Clinical Features Epidemiology Papillary hyperplasia is an uncommon entity, and no associations have been made regarding incidence or predisposing factors. They…
D efinition — A serous intraepithelial neoplasm of uncertain risk that does not fulfill the criteria for serous tubal intraepithelial carcinoma (STIC). Clinical Features Epidemiology Low-grade serous tubal intraepithelial neoplasia (STIN) is synonymous with a proliferation produced when there are…
D efinition — A limited clonal expansion of secretory cells associated with mutations in p53 exhibiting minimal or atypia. Seen as perhaps the very first step in serous carcinogenesis in the tube; often termed a “latent precursor” to pelvic serous…
D efinition — Benign, self-limited clonal proliferations of tubal secretory-type cells with variable ciliation. Clinical Features Epidemiology and Pathogenesis Secretory cell outgrowths (SCOUTs) are common proliferations seen most commonly in the sixth and seventh decades of life but may be…