In the minds of many students, the discipline of physiology is linked inextricably to images from its past. This prejudice is not surprising because many experiments from physiology's proud history, such as those of Pavlov on his dogs, have transcended…
Autosomal dominant polycystic kidney disease (ADPKD) (MIM 173900) is a systemic disorder characterized by age-dependent occurrence of bilateral, multiple renal cysts as well as a variety of extrarenal manifestations. The latter include cysts in the liver bile ducts, pancreatic ducts,…
Few cell types more elegantly embody the dictum that “form follows function” than do those of polarized epithelia. It is the unique architecture of renal epithelial cells that permits them to mediate vectorial transport. This transport, in turn, essentially determines…