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Introduction Deciding who should and who should not proceed with mechanical circulatory support (MCS)—including timing and device type—is one of the most difficult challenges in medicine. While there are now over 6 million people in the United States with heart…

Existing therapies slow, but rarely reverse, heart failure disease progression. As a result, the prevalence of symptomatic heart failure has increased, as has the length of time that people spend in later stages of the disease. At the far end…