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Dorchester Center, MA 02124
We have made significant advances in understanding of the pathogenesis and treatment of secondary hyperparathyroidism in chronic kidney disease (CKD). These include: (1) the discovery of the calcium-sensing receptor CaSR and the development of calcimimetics to target this receptor to…
Chronic kidney disease (CKD) alters the regulation of calcium, phosphate, and vitamin D homeostasis, leading to secondary hyperparathyroidism, elevations in serum fibroblast growth factor 23 (FGF23), metabolic bone disease, soft tissue calcifications, and other metabolic derangements that have a significant…