Tag Khaled J. Zaza

Historical Perspective After antibiotics came into widespread use in the 1940s and 1950s, the possibility that giving antibiotics perioperatively might prevent surgical site infection (SSI) became a matter of debate. Miles and colleagues used a guinea pig model to demonstrate…

Core body temperature is highly regulated in humans by the autonomic nervous system and the hypothalamus. General anesthesia, neuraxial anesthesia and analgesia, and drugs such as opioids all reduce the ability of the hypothalamus to regulate core temperature. Thus without…